Sometimes it's a bit complicated to explain what windows you need open and why; So, Imma just illustrate.
The windows you NEED are highlighted in blue. They are...
Initiative: This is the initiative list. When combat starts, you roll init. I add everyone's token to the list, then
you find and right click your token in the list, and set your initiative to what you rolled. Once everyone's got theirs listed, I can sort things out and start counting the rounds. You need this window open, so you can see when your turn is coming up and
be ready to act as soon as it is your turnChat: You need it to talk to people. Please make sure your text has a unique color, and disable automatic smiley insertion (in preferences).
Selected: You need this to edit your macros, which are stored on your token. At the moment, Roland is selected, so I can see all his macros. When you need to see, edit, or use your macros, you need to select your token. Please avoid using the global window for your macros, as, if I for some reason need to roll for your character, I can't access the macros unless they're on the token.
The other two windows are just handy.
Map Explorer: If you wind up lost, or zoomed retardedly, you can use this window to find your token again.
Connections: This just shows you who's connected to the server.
You don't have to arrange these windows in any particular way, just however they're comfortable, as long as you can access them easily.
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